Iron oxide loaded thermoresponsive micelles were formed by solvent-evaporation method. The amphiphilic block copolymer, P(NIPAAm-co-AAm)-b-PCL was synthesized by radical polymerization for copolymer and ring opening polymerization for block copolymer, respectively. We synthesized iron oxide nanoparticles having a narrow size distribution of 6 nm by the high-temperature diol reduction in benzyl ether. The micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block-poly(e-caprolaction), P(NIPAAm-co-AAm)-b-PCL, were combined with magnetic nanoparticles and drug which are self-assembled at the hydrophobic core. In our study, magnetic nanoparticles loaded thermoresponsive micelles were synthesized for the simultaneous magnetic hyperthermia and more » chemotherapy. Multifunctional magnetic nanoparticles with thermoresponsive polymer allowed the simultaneous cancer therapy because the functions of thermo triggered drug release and heating for hyperthermia can be performed simultaneously by applied magnetic field. Therefore, a simultaneous hyperthermia and chemotherapy can be a new approach for cancer treatment. Their sensitivity to chemotherapy after hyperthermia treatment is increased. The hyperthermia has a good synergic effect with chemotherapy. Hyperthermia has been shown to be a potentially effective therapeutic modality in cancer treatment as it intensifies the efficacy of chemotherapy. of Chicago, IL (United States) OSTI Identifier: 1357470 Grant/Contract Number: AC02-06CH11357 Resource Type: Accepted Manuscript Journal Name: Advanced Materials Interfaces Additional Journal Information: Journal Volume: 1 Journal Issue: 7 Journal ID: ISSN 2196-7350 Publisher: Wiley-VCH Country of Publication: United States Language: English Subject: 60 APPLIED LIFE SCIENCES nano-bio interfaces thermosensitive magnetomicelles drug delivery hard x-ray fluorescence nanoprobe sub-100 nm = , (ANL), Argonne, IL (United States) Sponsoring Org.: USDOE Office of Science (SC), Basic Energy Sciences (BES) Contributing Org.: Univ. Publication Date: Fri Jun 06 00:00: Research Org.: Argonne National Lab. In conclusion, by employing the magnetic functionality of the micelles and additionally loading them with a near infrared fluorescent dye, we magnetically target them to a tumor site in a live animal xenografted model which allows to visualize their biodistribution in vivo. We then study the cytotoxic effects of platinum complex-loaded micelles in vitro on a head and neck cancer cell culture model SQ20B. The distribution of a platinum complex on subcellular level is visualized using hard X-ray fluorescence microscopy with unprecedented level of detail at sub-100 nm spatial resolution. Nanomicelles with polymeric P(NIPAAm-co-AAm)-b-PCL core-shell were loaded with a hydrophobic Pt(IV) complex and Fe 3O 4 nanoparticles though self-assembly.
In this paper, we investigate the interaction between the hybrid magnetic nanomicelles engineered for controlled platinum complex drug delivery and a biological system at three fundamental levels: subcellular compartments, a single cell and whole living animal. In view of their potential biomedical applications, understanding the modes of interaction between nanomaterials and living systems and evaluation of efficiency of cargo delivery is of the utmost importance. Temperature-responsive magnetic nanomicelles can serve as thermal energy and cargo carriers with controlled drug release functionality.
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